Entries by Fernanda Fraga

KA Imaging’s CTO Dr. Karim S Karim Introduces Reveal 35C at IsDB Annual Meeting

Our CTO Karim S. Karim was one of the speakers on the sidelines of the 2021 Islamic Development Bank Group Annual Meeting in Uzbekistan. Dr. Karim introduced Reveal 35C as a solution for low and middle-income countries to screen for Covid-19 and other infectious diseases during the session “Showcase of Innovation of Tomorrow Powered by Transform Fund”.

“Health Care is governed by metrics of quality, cost and access,” said Karim. He continued: “When technologies come out, they tend to focus on just one of those aspects. It works in some societies, but it will not work out here [in mountainous regions]. Good technologies will achieve at least two of the requirements quality and cost; quality and access… But it’s very rare to find a technology that can meet quality, cost and access simultaneously. In the mountain regions of Central Asia access is critical. Everybody who has lived in a remote mountain community that gets blockaded 4 months in the winter because of snow will appreciate what I mean by access. Innovation is hard.  Reveal 35C is meant to address all 3 metrics of quality, cost and access.”  

The IsDB Meeting is held annually to discuss development issues and institutional matters, promoting partnerships, cooperation, and knowledge sharing.

Watch the session: 

Lung Tumor Localization – Visualizing Tumors and How Reveal 35C Can Help

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HOW dual-energy x-ray can help visualize lung tumors

The DE subtraction technique has superior sensitivity and aids in detecting any soft tissue abnormalities in the lungs. In fact, the 2013 study showed that DE imaging enhanced localization of lung tumors on 95% of the DE images

Reveal™ 35C’s detective quantum efficiency (DQE) is as high as 75%, and this higher DQE requires less
radiation to produce a better image. DE imaging showed improvement in the 2013 study by an average factor
of 4.7 compared to conventional X-rays without increasing image acquisition dose.

Read the blog post below for a summary of the article.


illustration showing lungs and tumorsLung cancer is the most commonly occurring cancer in the world, and the leading cause of malignancy-related deaths2. In the United States, lung cancer accounts for 13% of all cancer diagnoses, but 22% of all cancer deaths1.

In the US, approximately 154,000 lives are lost, and 228,000 people are diagnosed with lung cancer every year. Only 21% of those that are diagnosed survive five years or more1.

The process of diagnosis often includes X-ray and computed tomography (CT) to scan for abnormalities and masses, followed by biopsies and other testing to target therapy. There are many treatments available such as surgery, chemotherapy, and radiation therapy.

Diagnosis is often made only at advanced tumor stages due to the lack of visibility of many small growths. It is of the utmost importance to find lung cancer sooner so it can be treated more effectively in the future.

Tumors also need to be visualized to determine the treatment needed, and often must be localized multiple times throughout treatment, like in kV-based image-guided radiation.

The first known study on comparing dual-energy (DE) imaging to conventional X-ray imaging in terms of tumor visibility for patients undergoing this therapy (in 2013), showed that DE can play an important role3, and is a better solution than conventional X-ray.

Reveal 35C is KA Imaging’s portable dual-energy X-ray detector that can be a great option for localization of lung tumors to assist the process of radiotherapy treatment of lung cancer.

Here are some reasons why:

1. The DE subtraction technique has superior sensitivity and aids in detecting any soft tissue abnormalities in the lungs. In fact, the 2013 study showed that DE imaging enhanced localization of lung tumors on 95% of the DE images3.

 

2. Reveal’s Detective Quantum Efficiency (DQE) is as high as 75%, and this higher DQE requires less radiation to produce a better image. DE imaging showed improvement in the 2013 study by an average factor of 4.7 compared to conventional X-rays without increasing image acquisition dose3.

 

3. Reveal provides a high-quality conventional X-ray image, a bone-subtracted image, and a tissue-subtracted one in one shot. The unique triple-stacked layer design allows for easy integration and high quantum efficiency. The bone subtraction image could aid in the visualization of previously unseen small tumors. This study showed that DE subtraction resulted in the complete disappearance of overlying bone in 100% of the images3.

 

4. Only 12% of these images in the study had some motion artifacts3. The streaks that occur due to unavoidable motion, such as a human heartbeat, can invalidate images and mislead radiologists. This study noted that motion artifacts could be significantly reduced if a faster kV switching generator were used. Reveal could be an ideal alternative to kV switching techniques due to a single exposure detector design that entirely eliminates motion artifacts. This is only possible because Reveal’s multi-layer detector design obtains all images in a single exposure, unlike kV switching which requires a second exposure to obtain dual energy images.

 

Dual-energy subtraction could be a good solution to the shortcomings of accurate soft tissue visualization in conventional X-ray for the process of lung tumor localization during treatments for patients with lung cancer. DE images have been shown to produce clearer soft tissue (bone subtracted) images thus enabling better tumor visualization. KA Imaging’s dual-energy solution Reveal 35C is motion artifact free, portable, and completely retrofittable for any existing X-ray imaging infrastructure.

 

References

  1. Lung Cancer Statistics. LUNGevity. Lung Cancer Statistics | LUNGevity Foundation
  2. Lung Cancer Statistics. World Cancer Research Fund, American Institute for Cancer Research. Lung cancer statistics | World Cancer Research Fund (wcrf.org)
  3. Sherertz, T., Hoggarth, M., et al. (Aug. 30, 2013). Prospective Evaluation of Dual-Energy Imaging in Patients Undergoing Image Guided Radiation Therapy for Lung Cancer: Initial Clinical Results. International Journal of Radiation Oncology
  4. Tumors of the Lung. Radiology Key – Fastest Radiology Insight Engine. Tumors of the Lung | Radiology Key
  5. 30 Facts about Lung Cancer. Healthline. 30 Lung Cancer Facts: Statistics and (healthline.com)

 

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KA Imaging’s Flat Panel Sight™ Receives Medical Device Licence from Health Canada

KA Imaging’s Flat Panel Sight™ has received a Canadian Medical Device Licence from Health Canada. With the licence, the digital X-ray detector can be officially sold in Canada.

Among its main features, Sight™ can be called featherweight, as it weighs only 2.7 kilos in its 38 X 46cm version and 3.2 kilos in its 46 X 46cm version. In addition, Sight has a Wi-Fi option with a two-second image transfer. It is also IPX6 rated for water. AED allows use with any system.

“Sight™ is a powerful and affordable solution in the medical and veterinary fields”, says Karim S Karim, CTO of KA Imaging. “It is a product that came to complement KA’s line of solutions, so we can better address the different needs of radiologists, considering both technological and financial aspects,” says Amol Karnick, President and CEO of KA Imaging.

About KA Imaging

KA Imaging was founded in 2015 as a University of Waterloo spin-off. The company has successfully developed a line of innovative x-ray imaging products in the areas of micro-computed tomography, high efficiency x-ray area detection and multi-energy spectral separation detection. KA is proud to strive to understand the needs of its customers, ensuring to stay ahead of the innovation curve.

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X-ray After 125 Years

The Discovery

illustration of Wilhelm RöntgenIn 1895, German physicist Wilhelm Röntgen was studying electron beams when he made an accidental discovery4. He noticed that when he covered a Crookes tube (an early vacuum tube that produces electron beams) with cardboard, a faint glow came from a screen painted with fluorescent material that was some distance away, further than the electron beam could travel. Next, he realized that objects placed between the tube and the screen appeared transparent, although some more than others, depending on the material. He deduced that invisible rays other than the electron beam were coming from the tube and named them X-rays, due to their unknown nature. He was able to demonstrate his discovery to the world through the world’s first X-ray image that he took of his wife’s hand on a photographic plate that showed the bone structure within.

After significant advancements, at a time where people were becoming more excited about advancing technology, X-rays became a huge fad. Machines were used in shoe stores to check sizing from the 1920s to 1960s, and a hand-held toy was even made so children could take their own images at home. The dangers of radiation soon became evident after the use of nuclear bombs in World War II and exposure to X-rays was restricted to certain controlled applications.

The Basics

We understand now that X-rays are a type of radiation that can pass through the human body, and the rays are invisible and intangible. As they pass through an object, their energy is absorbed at different rates by different components within the object due to different atomic numbers. A detector on the other side of an object or body can transform these X-rays into an image to view and process.

Objects within a human body such as bones require higher energy X-rays to penetrate, which is why they appear clearly in the images. Softer tissue appears darker, as X-rays travel more easily through less dense materials with low atomic numbers like fat or muscle and air-filled cavities such as the lungs.

Applications

The main application of X-ray imaging has continued to be in the medical field, though X-ray imaging is also used for industrial, scientific and veterinary purposes. Röntgen, along with his colleagues, realized the importance of his discovery immediately and proceeded to study and experiment with enthusiasm.

We know a great deal more about X-rays now due to their persistence and have been able to integrate the use of X-rays into diagnostic procedures and medical care.

X-ray imaging is a cost-effective primary triaging and diagnostic tool for medical practitioners and helps to provide efficient care to patients presenting with illness or injury. It is a valued tool for a wide variety of examinations like diagnosing lung diseases or monitoring recovery, detecting bone fractures, supporting medical treatments, and guiding personnel as they insert devices into a patient’s body, or even treatment planning for cancer treatment.

Risks and Benefits

Of course, there have always been some risks, but these are much less threatening in modern times. X-ray imaging uses ionizing radiation, which potentially has enough energy to cause damage to DNA. There is a small chance that a person may develop cancer later in life, according to the FDA2, or have tissue damage causing cataracts, skin reddening or hair loss. These side-effects are extremely rare and depend on other variables and amount of radiation exposure.

The potential benefits of using X-ray imaging provide balance to these risks, and steps are taken to maintain the safest environment for patients and practitioners. Special care should be provided for children, pregnant women and those who are known to be more sensitive to radiation.  

 

Moving forward into the future

Areas of focus moving forward continue to be reducing radiation dose, improving image resolution, and enhancing materials and methods. Emerging companies like KA Imaging have taken strides in these areas and are producing new technology to support medical image quality and design by leveraging all parts of the X-ray spectrum. Reveal™ 35C, for example, brings new opportunities for portable, high-quality imaging without motion artifacts, capable of distinguishing between bone and soft tissue in one single shot, and improvements in X-ray dose by lowered exposure to the patient.

 

References

  1. Britannica – https://www.britannica.com/science/X-ray/Fundamental-characteristics

Reveal 35C Featured in FIND Report on Tuberculosis Screening

KA Imaging Inc. was featured in a report about digital chest radiography and computer-aided detection solution by Foundation for Innovative New Diagnostics. The Foundation for Innovative New Diagnostics (FIND) explores the market of radiology equipment and solutions for screening TB1, a disease that is ranked top 10 cause of deaths worldwide2

The purpose of the report is to help readers understand the different technologies used in performing chest X-ray radiography along with the progress of diagnostic X-ray imaging. Reveal™ 35C X-ray detector is the world’s first dual-energy detector, enabling bone and soft-tissue differentiation in one single exposure without motion artifacts. This new technology allows for better visualization, is highly affordable and can easily upgrade fixed and portable settings.  

Foundation for Innovative New Diagnostics partnered with World Health Organization and Stop TB to raise more awareness of the Tuberculosis epidemic. Nearly 4,000 people dies from TB every day1 but is unrecognized as the COVID-19 pandemic remains in the headline a year after.  

REFERENCES

1. Digital Chest Radiography and Computer-Aided Detection (CAD) Solutions for Tuberculosis Diagnostics. Foundation for Innovative New Diagnostics. Retrieved March 30, 2021 from https://www.finddx.org/wp-content/uploads/2021/03/Digital-CXR-CAD-solutions-for-TB-diagnosis-24Mar2021.pdf 

2. World Health Organization. (2020). Global Tuberculosis Report. Retrieved March 18, 2021 from https://apps.who.int/iris/bitstream/handle/10665/336069/9789240013131-eng.pdf 

March 24: World Tuberculosis Day

March 24 is World Tuberculosis Day. The date is celebrated to raise public awareness of all TB impacts. This disease has serious health, social and economic consequences. Find out more in the infographic below:

  1. World Health Organization. (2020). Global Tuberculosis Report. Retrieved 18, 2021 from https://apps.who.int/iris/bitstream/handle/10665/336069/9789240013131-eng.pdf
  2. World Health Organization. (2020). The End TB Strategy. Retrieved March 19, 2021 from https://www.who.int/tb/strategy/en/
  3. World Health Organization. (2015). Global strategy and targets for tuberculosis prevention, care and control after 2015. Retrieved March 18, 2021 from https://www.who.int/tb/post2015_TBstrategy.pdf?ua=1

Upgrade To Reveal 35C: an economic Proposition

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UPGRADE TO REVEAL 35C: AN ECONOMIC PROPOSITION

 

Dual energy has been shown to detect more solitary pulmonary nodules, pneumothorax, pneumonia, tuberculosis and coronary calcium than conventional analog or digital chest X-ray. This early detection enables better patient outcomes, additional hospital revenue, cost savings to healthcare systems and reduces exposure to malpractice claims.

KA Imaging has created Reveal™ 35C, the world’s first digital portable dual-energy X-ray detector as a universal upgrade for any analog or digital X-ray detector from any manufacturer. 

The infographic below summarizes the study.

UPGRADE TO REVEAL 35c: AN ECONOMIC PROPOSITION

Fill the form to receive the complete study in your email.


References

1.Oda, Seitaro, Kazuo Awai, Yoshinori Funama, Daisuke Utsunomiya, Yumi Yanaga, Koichi Kawanaka, Takeshi Nakaura et al. “Detection of small pulmonary nodules on chest radiographs: efficacy of dual-energy subtraction technique using flat-panel detector chest radiography.” Clinical radiology 65, no. 8 (2010): 609-615.

2.Martini, Katharina, Marco Baessler, Stephan Baumueller, and Thomas Frauenfelder. “Diagnostic accuracy and added value of dual-energy subtraction radiography compared to standard conventional radiography using computed tomography as standard of reference.” PloS one 12, no. 3 (2017): e0174285.

3.Urbaneja, A., Dodin, G., Hoosu, G., et al. (2018) Added Value of Bone Subtraction in Dual-energy Digital Radiography in the Detection of Pneuomothorax: Impact of Reader Expertise and Medical Specialty. The Association of University Radiologists. Elsevier Inc.

4. Song, Yingnan, Hao Wu, Di Wen, Bo Zhu, Philipp Graner, Leslie Ciancibello, Haran Rajeswaran et al. “Detection of coronary calcifications with dual energy chest X-rays: clinical evaluation.” The International Journal of Cardiovascular Imaging (2020): 1-8.

5.Sharma, Madhurima, Manavjit Singh Sandhu, Ujjwal Gorsi, Dheeraj Gupta, and Niranjan Khandelwal. “Role of digital tomosynthesis and dual energy subtraction digital radiography in detection of parenchymal lesions in active pulmonary tuberculosis.” European Journal of Radiology 84, no. 9 (2015): 1820-1827.

6.Kuhlman, Janet E., Jannette Collins, Gregory N. Brooks, Donald R. Yandow, and Lynn S. Broderick. “Dual-energy subtraction chest radiography: what to look for beyond calcified nodules.” Radiographics 26, no. 1 (2006): 79-92.

7.https://www.who.int/news-room/fact-sheets/detail/cancer

8.Song, Yingnan, Hao Wu, Di Wen, Bo Zhu, Philipp Graner, Leslie Ciancibello, Haran Rajeswaran et al. “Detection of coronary calcifications with dual energy chest X-rays: clinical evaluation.” The International Journal of Cardiovascular Imaging (2020): 1-8.

9.https://www.who.int/health-topics/cardiovascular-diseases#tab=tab_1

10.Divino, V., etal “The annual economic burden among patients hospitalized for community-acquired pneumonia (CAP): a retrospective US cohort study.” Current Medical Research and Opinion 36, no. 1 (2020): 151-160.

11.https://www.healthgrades.com/quality/patient-safety-2020-infographic

12.Domino etal, “Injuries and Liability Related to Central Vascular Catheters–A Closed Claims Analysis”, Anesthesiology 2004; 100:1411-8.

* Contact us to see the full study

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KA Imaging to Present at the 31st Annual Oppenheimer Healthcare Conference

WATERLOO, ON (March 15, 2021) – KA Imaging, a company that develops innovative X-ray imaging solutions, announced that management will deliver a company presentation at the 31st Annual Oppenheimer Healthcare Conference on Tuesday, March 16, 2021 at 8:00 a.m. ET.

The virtual presentation will be broadcast live and archived on the Company’s website at under “News and Events” in the About Us section.

About KA Imaging

A spin-off from the University of Waterloo, KA Imaging specializes in developing innovative X-ray imaging technologies and systems, providing solutions to the medical, veterinary, and non-destructive test industrial markets. For more information, please visit www.kaimaging.com.

Contact:

Stephen Kilmer

Investor Relations

skilmer@kaimaging.com

T: 647.872.4849

The Detection of Pneumothorax and How Dual-Energy Can Help

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KA Imaging is committed to protecting and respecting your privacy, and we’ll only use your personal information to administer your account and to provide the products and services you requested from us. From time to time, we would like to contact you about our products and services, as well as other content that may be of interest to you. If you consent to us contacting you for this purpose, please tick below to say how you would like us to contact you:



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how dual-energy x-ray can help detect pneumothorax

 

Dual-energy bone subtraction radiographs yielded the greatest increase in detection, even when used alone. The study reported the positive result in diagnostic performance with a sensitivity and specificity for pneumothorax detection as 82% and 92%, compared to 70% and 84% in sensitivity and specificity for conventional radiographs. The physicians in this case recommended the use of dual-energy bone subtraction for suspected pneumothorax without hesitation.

Read the blog post below for a summary of the article.


Pneumothorax, or a collapsed lung that occurs when air enters the space around the lungs, is a condition that poses diagnostic problems. Although common tests, such as lung sonography, ultrasound, CT scan and X-ray are often performed, some cases may be misdiagnosed. This could present a life-threatening situation due to the immediate treatments often needed for this medical emergency.

Several studies on patient safety look at iatrogenic (caused by medical procedure) pneumothorax in American hospitals. Healthgrades 2020 Patient Safety Excellence Award infographic reported that from 2016-2018 there were more than 44,000 Medicare patients in U.S. hospitals diagnosed with a collapsed lung due to a procedure in or around the chest alone. There are also at least 10,000 cases per year in Canada2.

A recent study in France, published in 2018, calls the condition common and reports 17 out of 100,000 people are affected there, with 34.8 out of 100,000 people in England estimated to be affected by pneumothorax as well4.

A team of doctors studied the detection of pneumothorax and the value of using dual-energy digital radiography, as well as the impact of medical specialty. They looked at forty patients with a suspected pneumothorax and divided them into groups based on their final diagnosis – whether they were thought to have this issue or not. They were able to compare and analyze standard images, dual-energy bone subtracted images and a combination in specific sessions. Doctors with various levels of expertise were included in the study.

They found that bone subtracted dual-energy thoracic radiographs improved the detection of pneumothorax, including small pneumothoraxes, regardless of the medical specialty or reader’s level of expertise.

In fact, dual-energy bone subtraction radiographs yielded the greatest increase in detection, even when used alone. The study reported the positive result in diagnostic performance with a sensitivity and specificity for pneumothorax detection as 82% and 92%, compared to 70% and 84% in sensitivity and specificity for conventional radiographs4. The physicians in this case recommended the use of dual-energy bone subtraction for suspected pneumothorax without hesitation.

Dual-energy radiography is an expanding technique and has demonstrated improvement in the detection of calcified and noncalcified lung nodules, and calcified thoracic lesions, mediastinal, pleural, or pulmonary. This technique supresses bone structures of the thoracic wall, reduces superimposition and allows for finer delimitation of lung contours.

KA Imaging’s Reveal, a dual-energy X-ray detector that has received USA FDA 510 (k) clearance as well as a Health Canada Medical Device Licence, is a unique and fitting solution to help in the diagnostic process. 

Reveal is a portable detector that enables bone and soft-tissue differentiation without motion artifacts in a single X-ray exposure. It can replace existing X-ray detectors and is also retrofittable to existing X-ray systems. Reveal increases sensitivity compared to conventional X-ray to aid in the early diagnosis and monitoring of pulmonary conditions. It is much more affordable than other fixed dual-energy systems, at less than a quarter of the price, and can be taken right to a patient’s bedside in an emergency room setting.

Reveal uses significantly less radiation than a CT and provides clearer images than a conventional X-ray. In one shot, the detector simultaneously delivers DR, bone, and tissue images.

References

  1. Right Diagnosis from Healthgrades. Statistics about Pneumothorax. https://www.rightdiagnosis.com/p/pneumothorax/stats.htm
  2. Healthgrades. Patient Safety 2020 Infographic. https://www.healthgrades.com/quality/patient-safety-2020-infographic
  3. Reed, K. May, R., et al. (2011) Healthgrades Patient Safety in American Hospitals Study. HealthGrades, Guiding America to Better Healthcare. https://patientsafetymovement.org/wp-content/uploads/2016/02/Resources_Reports_Patient_Safety_in_American_Hospitals_Study.pdf
  4. Urbaneja, A., Dodin, G., Hoosu, G., et al. (2018) Added Value of Bone Subtraction in Dual-energy Digital Radiography in the Detection of Pneuomothorax: Impact of Reader Expertise and Medical Specialty. The Association of University Radiologists. Elsevier Inc.

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KA Imaging Further Strengthens Executive Team with Appointment of World-Renowned Radiologist, Dr. Philip Templeton, as Chief Medical Officer

A board certified radiologist, Dr. Templeton brings over 38 years of academic and entrepreneurial medicine experience to KA Imaging. Dr. Templeton is most recently known as Cofounder and Chief Medical Officer of DocPanel Technologies. A graduate and valedictorian at the University of Rochester School of Medicine, he did his internship in Medicine at the Georgetown University Hospital. His radiology residency was at the University of Maryland, where he also served as Chief Resident. He undertook his Thoracic Radiology Fellowship at the Massachusetts General Hospital. He served as Professor and Chairman of University of Maryland Radiology for ten years. Dr. Templeton was inducted as a Fellow of the American College of Radiology in 2000.

Among his many career accomplishments, Dr. Templeton was a pioneer in the use of several groundbreaking technologies, including CT fluoroscopy, digital X-ray, PACS and teleradiology.

“In addition to being a skilled physician, Dr. Templeton is a seasoned corporate leader with a strong track record of delivering medical, scientific and strategic guidance to both established and emerging companies in the medical imaging space,” said Amol Karnick, CEO of KA Imaging. “We are delighted to welcome him as CMO. Dr. Templeton will provide a strong liaison with our customers, and ensure that our clinical programs are designed to meet the needs of both clinicians and patients.”

Dr. Templeton’s appointment comes on the heels of the recent additions of two other seasoned industry veterans – Shawn Campbell as Vice President of Operations and Robert Moccia as Vice President of Sales, USA and Canada – as KA Imaging executes its commercial roll-out of Reveal™ 35C, the world’s first portable, single exposure, dual-energy X-ray detector that enables bone and soft tissue differentiation without motion artifacts.

About KA Imaging

A spin-off from the University of Waterloo, KA Imaging specializes in developing innovative X-ray imaging technologies and systems, providing solutions to the medical, veterinary, and non-destructive test industrial markets. For more information, please visit www.kaimaging.com.

Contacts

Fernanda Fraga
Media Relations
ffraga@kaimaging.com
T: 226.215.9897

Stephen Kilmer
Investor Relations
skilmer@kaimaging.com
T: 647.872.4849